Rolf F Kletzien, PhD

Rolf F Kletzien, PhD
Rolf F Kletzien, PhD

Research Professor, Department of Biomedical Sciences

Contact Information

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Biosketch

Rolf Kletzien, PhD, is co-founder, senior vice president-research, and a board member for Metabolic Solutions Development Company (MSDC) in Kalamazoo, Michigan, a drug discovery and development company investigating new molecular targets and developing novel therapeutics to treat metabolic diseases associated with age-related mitochondrial dysfunction, especially insulin resistance and type 2 diabetes.

Dr. Kletzien is a graduate of University of Wisconsin in Madison, Wisconsin. He also earned his doctorate in oncology from University of Wisconsin.

Prior to founding MSDC, Dr. Kletzien worked for The Upjohn Company, Pharmacia & Upjohn, Pharmacia Corporation, and Pfizer Corporation most recently, where he served as vice president of genomics & biotechnology. He has four patents to his name and has extensive research grant experience. He also has a considerable publication list, with more than 70 articles he has contributed to.

  • 汤头条app and Training
    • PhD 1974, Oncology, University of Wisconsin-Madison
    • BS 1970, Biochemistry, University of Wisconsin-Madison

  • Research
    • Oncology
    • Molecular Biology
    • Biochemistry

  • Publications

    • Colca J.R., Tanis S.P., Kletzien R.F., Finck B.N. Expert Opinion on Investigational Drugs. 2023;32:803-811.

    • Kletzien R.F., Berdanier C.D. Glucose-6-phosphate dehydrogenase: Diet and hormonal influences on de novo enzyme synthesis Nutrition and Gene Expression. 2018:187-206.

    • Tanis S.P., Colca J.R., Parker T.T., Artman G.D., Larsen S.D., McDonald W.G., Gadwood R.C., Kletzien R.F., Zeller J.B., Lee P.H., Adams W. Bioorganic and Medicinal Chemistry. 2018;26(22):5870-5884.

    • Vigueira P., McCommis K.S., Hodges W.T., Schweitzer G.G., Cole S.L., Oonthonpan L., Taylor E.B., McDonald W.G., Kletzien R.F., Colca J.R., Finck B.N. Experimental Physiology. 2017;102(8):985-999.

    • McCommis K.S., Chen Z., Fu X., McDonald W.G., Colca J.R., Kletzien R.F., Burgess S.C., Finck B.N. Cell Metabolism. 2015;22(4):682-694.

    • Colca J., Mcdonald W., Kletzien R. Diabetes, Obesity and Metabolism. 2014;16(11):1048-1054.

    • Colca J., Tanis S., McDonald W., Kletzien R. Expert Opinion on Investigational Drugs. 2014;23(1):1-7.

    • Vigueira P., McCommis K.S., Schweitzer G.G., Remedi M.S., Chambers K.T., Fu X., McDonald W.G., Cole S.L., Colca J.R., Kletzien R.F., Burgess S.C., Finck B.N. Cell Reports. 2014;7(6):2042-2053.

    • Colca J.R., McDonald W.G., Cavey G.S., Cole S.L., Holewa D., Brightwell-Conrad A.S., Wolfe C.L., Wheeler J.S., Coulter K.R., Kilkuskie P.M., Gracheva E., Korshunova Y., Trusgnich M., Karr R., Wiley S.E., Divakaruni A.S., Murphy A.N., Vigueira P.A., Finck B.N., Kletzien R.F. PLoS ONE. 2013;8(5)

    • Rohatgi N., Aly H., Marshall C.A., McDonald W.G., Kletzien R.F., Colca J.R., McDaniel M.L. PLoS ONE. 2013;8(5)

    • Chen Z., Vigueira P.A., Chambers K.T., Hall A.M., Mitra M.S., Qi N., McDonald W.G., Colca J.R., Kletzien R.F., Finck B.N. Journal of Biological Chemistry. 2012;287(28):23537-23548.

    • Colca J.R., Kletzien R.F. Advances in pharmacology (San Diego, Calif.). 2009;57:237-251.

    • Colca J., Kletzien R. Expert Opinion on Investigational Drugs. 2006;15(3):205-210.

    • Sadhukhan R., Leone J., Lull J., Wang Z., Kletzien R., Heinrikson R., Tomasselli A. Protein Expression and Purification. 2006;46(2):299-308.

    • Qahwash I., He W., Tomasselli A., Kletzien R.F., Yan R. Journal of Biological Chemistry. 2004;279(37):39010-39016.

    • Qahwash I., Weiland K.L., Lu Y., Sarver R.W., Kletzien R.F., Yan R. Journal of Biological Chemistry. 2003;278(25):23187-23195.

    • Ulrich R., Cramer C., Adams L., Kletzien R. Cell Biochemistry and Function. 1998;16(2):77-85.

    • Stapleton S., Garlock G., Foellmi-Adams L., Kletzien R. Biochimica et Biophysica Acta - Molecular Cell Research. 1997;1355(3):259-269.

    • Foellmi-Adams L.A., Wyse B.M., Herron D., Nedergaard J., Kletzien R.F. Biochemical Pharmacology. 1996;52(5):693-701.

    • Harris P., Foehmi-Adams L., Kletzien R. JNK activation in 3T3-L1 cells by tumor necrosis factor- (TNF-伪) FASEB Journal. 1996;10(6)

    • Heinrikson R.L., Manning A.M. Journal of Biological Chemistry. 1996;271(33):19680-19688.

    • Cramer C., Cooke S., Ginsberg L., Kletzien R., Stapleton S., Ulrich R. Journal of Biochemical Toxicology. 1995;10:293-298.

    • Harris P.K.W., Kletzien R.F. Molecular Pharmacology. 1994;45(3):439-445.

    • Kletzien R.F., Harris P.K.W., Foellmi L.A. FASEB Journal. 1994;8(2):174-181.

    • Stapleton S.R., Stevens G.J., Teel J.F., Rank K., Berg E.A., Wu J.Y., Ginsberg L.C., Kletzien R.F. Biochimie. 1993;75:971-976.

    • Kletzien R.F., Clarke S.D., Ulrich R.G. Molecular Pharmacology. 1992;41(2):393-398.

    • Kletzien R.F., Foellmi L.A., Harris P.K.W., Wyse B.M., Clarke S.D. Molecular Pharmacology. 1992;42(4):558-562.

    • Ulrich R., Aspar D., Cramer C., Kletzien R., Ginsberg L. In Vitro Cellular &Developmental Biology. 1990;26:815-823.

    • Prostko C.R., Fritz R.S., Kletzien R.F. Biochemical Journal. 1989;258(1):295-299.

    • Fritz R.S., Kletzien R.F. Molecular and Cellular Endocrinology. 1987;51(1-2):13-17.

    • McClung J., Ulrich R., Kletzien R. Molecular and Cellular Biochemistry. 1987;73(1):21-27.

    • Fritz R.S., Stumpo D.J., Kletzien R.F. Biochemical Journal. 1986;237(2):617-619.

    • McClung J.K., Johnson R.R., Kletzien R.F. Microinjection of the catalytic subunit of cyclic adenosine 3',5'-monophosphate dependent protein kinase into a human mammary carcinoma cell line Journal of Nutrition Growth and Cancer. 1986;3(1):13-22.

    • McClung J.K., Dreher K.L. Journal of Biological Chemistry. 1985;260(9):5621-5624.

    • Prostko C.R., Kletzien R.F. Regulation of hepatic mRNA coding for glucose-6-phosphate dehydrogenase Federation Proceedings. 1985;44(3)

    • Stumpo D.J., Kletzien R.F. Biochemical Journal. 1985;226(1):123-130.

    • Stumpo D.J., Prostko C.R., Kletzien R.F. Alcohol. 1985;2(1):169-172.

    • Kelley D.S., Kletzien R.F. Biochemical Journal. 1984;217(2):543-549.

    • McClung J.K., Kletzien R.F. Molecular and Cellular Biology. 1984;4(6):1079-1085.

    • STUMPO D.J., KLETZIEN R.F. European Journal of Biochemistry. 1984;144(3):497-502.

    • Stumpo D.J., Kletzien R.F. Glucocorticoid and insulin regulation of hepatic mRNA coding for glucose-6-phosphate dehydrogenase Federation Proceedings. 1984;43(7)

    • Kletzien R.F., Weber C.A., Butcher F.R., Stumpo D.J. Journal of Cellular Physiology. 1982;110(3):304-310.

    • Quinlan D., Todderud C., Kelley D., Kletzien R. Biochemical Journal. 1982;208(3):685-693.

    • Weber C.A., Kletzien R.F. Journal of Cellular Physiology. 1982;110(3):300-303.

    • Keith Mcclung J., Kletzien R.F. BBA - General Subjects. 1981;676(3):300-306.

    • Kletzien R. The Biochemical journal. 1981;196(3):853-859.

    • Kletzien R.F., Weber C.A., Stumpo D.J. Journal of Cellular Physiology. 1981;109(1):83-90.

    • Stumpo D.J., Kletzien R.F. Journal of Cellular Physiology. 1981;107(1):11-19.

    • Gross R.L., Kletzien R.F., Butcher F.R. Biochimica et Biophysica Acta - Biomembranes. 1980;602(3):635-643.

    • Kletzien R. Biochemical Journal. 1980;192(2):753-759.

    • Kletzien R.F. Coordinate regulation of the phosphorylation state of pyruvate kinase by glucocorticoids and cyclic AMP Journal of Cell Biology. 1980;87(2 II)

    • Kletzien R.F., Day P. Journal of Cellular Physiology. 1980;105(3):533-539.

    • Stumpo D.J., Kletzien R.F. Glucocorticoid permissive effects on glucagon-stimulated gluconeogenesis in primary cultures of adult rat liver parenchymal cells Journal of Cell Biology. 1980;87(2 II)

    • Todderud C.G., Kletzien R.F. Hormonal regulation of plasma membrane protein synthesis Journal of Cell Biology. 1980;87(2 II)

    • Pardee A., Dubrow R., Hamlin J., Kletzien R. Annual review of biochemistry. 1978;47:715-750.

    • Kletzien R.F., Miller M., Pardee A.B. Nature. 1977;270(5632):57-59.

    • Phillips E., Kletzien R., Perdue J. Experimental Cell Research. 1977;105(1):51-62.

    • Kletzien R., Pariza M., Becker J., Potter V. Journal of Cellular Physiology. 1976;89(4):641-646.

    • Kletzien R., Perdue J. Journal of Cellular Physiology. 1976;89(4):723-728.

    • Pariza M.W., Butcher F.R., Kletzien R.F., Becker J.E., Potter V.R. Proceedings of the National Academy of Sciences of the United States of America. 1976;73(12):4511-4515.

    • Pariza M.W., Kletzien R.F., Butcher F.R., Potter V.R. Advances in Enzyme Regulation. 1976;14(C):103-115.

    • Potter V.R., Butcher F.R. Journal of Biological Chemistry. 1976;251(10):3014-3020.

    • Kletzien R., Pariza M., Becker J., Potter V. Nature. 1975;256(5512):46-47.

    • Kletzien R., Pariza M., Becker J., Potter V. Analytical Biochemistry. 1975;68(2):537-544.

    • Kletzien R., Pariza M., Becker J., Potter V. Hormonal and metabolic regulation of amino acid transport and gluconeogenesis in primary cultures of adult rat liver parenchymal cells Federation Proceedings. 1975;34(3)

    • Kletzien R., Perdue J. Regulation of sugar transport in chick embryo fibroblasts infected with a temperature-sensitive mutant of RSV Cell. 1975;6(4):513-520.

    • Kletzien R.F., Perdue J.F. Journal of Biological Chemistry. 1975;250(2):593-600.

    • Kletzien R.F., Perdue J.F. Journal of Biological Chemistry. 1974;249(11):3366-3374.

    • Kletzien R.F., Perdue J.F. Journal of Biological Chemistry. 1974;249(11):3375-3382.

    • Kletzien R.F., Perdue J.F. Journal of Biological Chemistry. 1974;249(11):3383-3387.

    • Kletzien R., Perdue J. Sugar transport in fibroblasts treated with serum and transformed by a temperature sensitive mutant of the Rous sarcoma virus Federation Proceedings. 1973;32(3 (I)):124.

    • Kletzien R.F., Perdue J.F. Journal of Biological Chemistry. 1973;248(2):711-719.

    • Kletzien R.F., Perdue J.F., Springer A. Journal of Biological Chemistry. 1972;247(9):2964-2966.

    • Perdue J.F., Kletzien R., Wray V.L. BBA - Biomembranes. 1972;266(2):505-510.

    • Perdue J.F., Kletzien R., Miller K. BBA - Biomembranes. 1971;249(2):419-434.

    • Perdue J.F., Kletzien R., Miller K., Pridmore G., Wray V.L. BBA - Biomembranes. 1971;249(2):435-453.