Nichol E Holodick, PhD

Nichol E Holodick, PhD
Nichol E Holodick, PhD

Associate Professor, Department of Investigative Medicine

Biosketch

Dr. Holodick performed her undergraduate work at Northeastern University in Boston, Massachusetts. She obtained her PhD in Immunology from Boston University in 2009, working on signaling and development of B-1 cells. Dr. Holodick expanded her work on B-1 cells during a postdoctoral fellowship at the Feinstein Institute for Medical Research in Manhasset, New York. During this time, she focused her research on the role of B-1 cells in infection during aging. Recently, Dr. Holodick was appointed to Assistant Professor in the Center for Immunobiology and Department of Biomedical Sciences at Western Michigan University School of Medicine. She currently studies the role of B-1 cells in protection from pneumococcal infection in sickle cell disease and B-1 cell development in young and aged mice.

  • 汤头条app and Training
    • PhD 2009, Immunology, Boston University
    • BS 2003, Biology, Northeastern University

  • Publications

    • Gutknecht M.F., Holodick N.E., Rothstein T.L. B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells iScience. 2023;26

    • Webster S.E., Tsuji N.L., Clemente M.J., Holodick N.E. Frontiers in Immunology. 2023;13

    • Srikakulapu P., Pattarabanjird T., Upadhye A., Bontha S.V., Osinski V., Marshall M.A., Garmey J., Deroissart J., Prohaska T.A., Witztum J.L., Binder C.J., Holodick N.E., Rothstein T.L., McNamara C.A. Frontiers in Immunology. 2022;13

    • Webster S.E., Ryali B., Clemente M.J., Tsuji N.L., Holodick N.E. Journal of Immunology. 2022;208:1755-1771.

    • Tsuji N., Rothstein T.L., Holodick N.E. Journal of immunology (Baltimore, Md. : 1950). 2020;205:741-759.

    • Ghosn E., Dorshkind K., Herzenberg L.A., Holodick N., Kantor A., Montecino-Rodriguez E., Rothstein T.L., Silverman G., Yang Y., Yoder M.C., Yoshimoto M. Science. 2019;364:248.

    • Upadhye A., Srikakulapu P., Gonen A., Hendrikx S., Perry H.M., Nguyen A., McSkimming C., Marshall M.A., Garmey J.C., Taylor A.M., Bender T.P., Tsimikas S., Holodick N.E., Rothstein T.L., Witztum J.L., McNamara C.A. Circulation research. 2019;125:e55-e70.

    • Aziz M., Ode Y., Zhou M., Ochani M., Holodick N., Rothstein T., Wang P. Molecular Medicine. 2018;24

    • Aziz M., Holodick N., Rothstein T., Wang P. Journal of Immunology. 2017;199(2):750-760.

    • Hernandez A., Holodick N. Editorial: Natural antibodies in health and disease Frontiers in Immunology. 2017;8(DEC)

    • Holodick N., Rodr铆guez-Zhurbenko N., Hern谩ndez A. Defining natural antibodies Frontiers in Immunology. 2017;8(JUL)

    • Kaku H., Holodick N., Tumang J., Rothstein T. CD25<sup>+</sup> B-1a cells express Aicda Frontiers in Immunology. 2017;8

    • Mart铆nez D., Pupo A., Cabrera L., Raymond J., Holodick N.E., Hern谩ndez A.M. Journal of Immunology Research. 2017;2017

    • Holodick N., Vizconde T., Hopkins T., Rothstein T. Journal of Immunology. 2016;196(10):4348-4357.

    • Holodick N.E., Zeumer L., Rothstein T.L., Morel L. Expansion of B-1a cells with germline heavy chain sequence in lupus mice Frontiers in Immunology. 2016;7(MAR)

    • Kramer J.M., Holodick N.E., Vizconde T.C., Raman I., Yan M., Li Q.Z., Gaile D.P., Rothstein T.L. Journal of Leukocyte Biology. 2016;99(2):321-331.

    • Olofsson P.S., Steinberg B., Sobbi R., Cox M.A., Ahmed M.N., Oswald M., Szekeres F., Hanes W.M., Introini A., Liu S.F., Holodick N.E., Rothstein T.L., L枚vdahl C., Chavan S.S., Yang H., Pavlov V.A., Broliden K., Andersson U., Diamond B., Miller E.J., Arner A., Gregersen P.K., Backx P.H., Mak T.W., Tracey K.J. Nature Biotechnology. 2016;34(10):1066-1071.

    • Qu谩ch T.D., Hopkins T.J., Holodick N.E., Vuyyuru R., Manser T., Bayer R.L., Rothstein T.L. Journal of Immunology. 2016;197(10):3950-3958.

    • Rothstein T., Holodick N. Activation of B-1 Cells Encyclopedia of Immunobiology. 2016;3:237-243.

    • Aziz M., Holodick N.E., Rothstein T.L., Wang P. Immunologic Research. 2015;63(1-3):153-166.

    • Holodick N., Rothstein T. Annals of the New York Academy of Sciences. 2015;1362(1):176-187.

    • Rothstein T., Herzenberg L., Holodick N., Ghosn E. Annals of the New York Academy of Sciences. 2015;1362(1):v-vi.

    • Holodick N., Vizconde T., Rothstein T. Journal of Immunology. 2014;192(5):2432-2441.

    • Holodick N., Vizconde T., Rothstein T. Splenic B-1a cells expressing CD138 spontaneously secrete large amounts of immunoglobulin in na茂ve mice Frontiers in Immunology. 2014;5(MAR)

    • Chen S., Batliwalla F., Holodick N., Yan X., Yancopoulos S., Croce C., Rothstein T., Chiorazzi N. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(16)

    • Holodick N., Rothstein T. Atypical response of B-1 cells to BCR ligation: A speculative model Frontiers in Immunology. 2013;4(DEC)

    • Rothstein T., Griffin D., Holodick N., Quach T., Kaku H. Human B-1 cells take the stage Annals of the New York Academy of Sciences. 2013;1285:97-114.

    • Griffin D., Quach T., Batliwalla F., Andreopoulos D., Holodick N., Rothstein T. Journal of Experimental Medicine. 2012;209(3):434-436.

    • Griffin D., Holodick N., Rothstein T. Correction: Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20<sup>+</sup>CD27<sup>+</sup>CD43<sup>+</sup>CD70<sup>-</sup> Journal of Experimental Medicine. 2011;208(4):871.

    • Griffin D., Holodick N., Rothstein T. Journal of Experimental Medicine. 2011;208(1):67-80.

    • Griffin D., Holodick N., Rothstein T. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20<sup>+</sup>CD27<sup>+</sup>CD43<sup>+</sup>CD70<sup>-</sup> (The Journal of Experimental Medicine (2011), 208, 1, (67-80)) Journal of Experimental Medicine. 2011;208(2):409.

    • Griffin D.O., Holodick N.E., Rothstein T.L. Journal of Experimental Medicine. 2011;208(13):2566-2569.

    • Tumang J.R., Holodick N.E., Vizconde T.C., Kaku H., Franc茅s R., Rothstein T.L. A CD25<sup>-</sup> positive population of activated B1 cells expresses LIFR and responds to LIF Frontiers in Immunology. 2011;2

    • Holodick N., Tumang J., Rothstein T. European Journal of Immunology. 2010;40(11):3007-3016.

    • Holodick N., Tumang J., Rothstein T. Molecular Immunology. 2009;46(15):3029-3036.

    • Holodick N.E., Repetny K., Zhong X., Rothstein T.L. European Journal of Immunology. 2009;39(9):2383-2394.

    • Repetny K.J., Zhong X., Holodick N.E., Rothstein T.L., Hansen U. European Journal of Immunology. 2009;39(5):1387-1394.

    • Zhong X., Lau S., Bai C., Degauque N., Holodick N., Steven S., Tumang J., Gao W., Rothstein T. Arthritis and Rheumatism. 2009;60(12):3734-3743.

    • Husain Z., Holodick N., Day C., Szymanski I., Alper C. Journal of Clinical Immunology. 2006;26(2):113-125.

    • Barrington R.A., Zhang M., Zhong X., Jonsson H., Holodick N., Cherukuri A., Pierce S.K., Rothstein T.L., Carroll M.C. Journal of Immunology. 2005;175(5):2859-2867.

  • Presentations
    • Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Webster SE, Tsuji N, Clemente MJ, Holodick NE, Gordon Research Conference: Sex Differences in Immunity, Ventura, California, 04/2923
    • Loss of estrogen signaling alters B-1 cells in a model of polycystic ovarian syndrome. Vergara R, Webster S, Hurley I, Holodick N, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
    • Analysis of the B-1 cell repertoire post-Pneumovax23 vaccination in a mouse model of sickle cell disease. Les SM, Tsuji NL, Holodick NE, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
    • Impact of TLR stimulation on the CD5+ and CD5- B-1 cell repertoires with age. Helmich M, Webster S, Tsuji N, Holodick N, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
    • B Cell-Derived Natural IgM Maintains Retinal Homeostasis throughout Lifespan. Les SM, Webster SE, Heck DM, Jones P, Clemente MJ, Holodick NE, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
    • Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Holodick N, Department of Microbiology Seminar at Miami University, Oxford, Ohio, 04/2023
    • Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Holodick N, Gordon Research Conference: Sex Differences in Immunity, Ventura, California, 04/2023
    • Under Pressure: Genetic and Sex-Based Influences on Natural Antibodies and Natural Antibody Producing Cells. Webster SE, Vergara R, Tsuji N, Heck D, Clemente MJ, Holodick NE, Gordon Research Conference: Sex Differences in Immunity, Ventura, California, 04/2023
    • Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Holodick N, Department of Biological Sciences Seminar at Western Michigan University, Kalamazoo, Michigan, 04/2023
    • Influence of age, sex, and environment on the diversity of the murine gut microbiome and expression of pro-inflammatory cytokines. Webster S, Vos D, Rothstein T, Holodick N, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
    • Immunoglobulin M is Packaged into B Cell-Derived Extracellular Vesicles and Can Be Transferred to Secondary Cells. Gutknecht M, Holodick N, Rothstein T, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
    • Characterization of Immunoglobulin M in B-Cell-Derived Extracellular Vesicles. Gutknecht M, Holodick N, Rothstein T, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
    • Differential Gene Expression in Aged B Cells: A Role for Sex. Ryali B, Holodick N, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
    • The Role of IgM in Selection of the Murine B-1A Cell Repertoire with Increasing Age. Ewing P, Tsuji N, Holodick N, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
    • Analysis of B cell progenitors in sickle cell disease. Chou J, Holodick N, 36th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2019