Frederick Stull, PhD

Frederick Stull, PhD
Frederick Stull, PhD

Adjunct Assistant Professor, Department of Biomedical Sciences

Contact Information

Email:

Biosketch

Frederick Stull, PhD, is an assistant professor in the Department of Chemistry at Western Michigan University. He graduated from the University of South Florida, Tampa, Florida. He earned his doctorate in chemical biology from the University of Michigan, Ann Arbor, Michigan. The overarching goal of Dr. Stull's research is to understand how enzymes control catalysis. The Stull lab primarily focuses on the class of enzymes that use riboflavin-derived cofactors (flavin-dependent enzymes), which catalyze various chemical transformations crucial for life. Enzyme-bound flavin cofactors have spectroscopic signals that directly report on the chemistry occurring in the active site, which Stull's lab exploits to study their reaction mechanisms using transient kinetics. The Stull lab also uses directed evolution and protein engineering to transform nature's catalysts into useful tools for biotechnology/medical applications.

  • 汤头条app and Training
    • Postdoctoral Fellowship 2019, Chemical Biology, Howard Hughes Medical Institute
    • PhD 2014, Chemical Biology, University of Michigan
    • BS 2009, Chemistry, University of South Florida

  • Research
    • Protein Engineering
    • Enzyme Catalysis
    • Directed Molecular Evolution
    • Biotechnology
    • Biomedical applications

  • Publications

    • Javanshad R., Taylor C.J., Delavari N., Barkman T.J., Stull F., Venter A.R. Rapid Communications in Mass Spectrometry. 2023;37

    • Choudhary V., Wu K., Zhang Z., Dulchavsky M., Barkman T., Bardwell J.C.A., Stull F. Journal of Biological Chemistry. 2022;298(8)

    • Matthews A., Sch枚nfelder J., Lagies S., Schleicher E., Kammerer B., Ellis H.R., Stull F., Teufel R. FEBS Journal. 2022;289(3):787-807.

    • Meredith J.D., Chapman I., Ulrich K., Sebastian C., Stull F., Gray M.J. Proceedings of the National Academy of Sciences of the United States of America. 2022;119(30)

    • Mumby E.J., Willoughby J.A., Vasquez C., Delavari N., Zhang Z., Clark C.T., Stull F. Biochemistry. 2022;61(20):2182-2187.

    • Bou-Nader C., Stull F.W., Pecqueur L., Simon P., Gu茅rineau V., Royant A., Fontecave M., Lombard M., Palfey B.A., Hamdane D. Nature Communications. 2021;12(1)

    • Dulchavsky M., Clark C.T., Bardwell J.C.A., Stull F. Nature Chemical Biology. 2021;17(3):344-350.

    • Dulchavsky M., Clark C.T., Bardwell J.C.A., Stull F. Nature Chemical Biology. 2021;17(3):360.

    • Matthews A., Saleem-Batcha R., Sanders J.N., Stull F., Houk K.N., Teufel R. Nature Chemical Biology. 2020;16(5):556-563.

    • Meinen B.A., Gadkari V.V., Stull F., Ruotolo B.T., Bardwell J.C.A. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(46):23040-23049.

    • Saleem-Batcha R., Stull F., Sanders J.N., Moore B.S., Palfey B.A., Houk K.N., Teufel R. Proceedings of the National Academy of Sciences of the United States of America. 2019;116(30):15309.

    • Wu K., Stull F., Lee C., Bardwell J.C.A. Nature Communications. 2019;10(1)

    • Horowitz S., Koldewey P., Stull F., Bardwell J. Current Opinion in Structural Biology. 2018;48:1-5.

    • Saleem-Batcha R., Stull F., Sanders J.N., Moore B.S., Palfey B.A., Houk K.N., Teufel R. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(19):4909-4919.

    • Salmon L., Stull F., Sayle S., Cato C., Akg眉l 艦., Foit L., Ahlstrom L.S., Eisenmesser E.Z., Al-Hashimi H.M., Bardwell J.C.A., Horowitz S. Journal of Molecular Biology. 2018;430(1):33-40.

    • Stull F., Bardwell J. Nature Chemical Biology. 2018;14(4):329-330.

    • Stull F., Betton J.M., Bardwell J.C.A. EcoSal Plus. 2018;8(1)

    • Stull F., Hipp H., Stockbridge R., Bardwell J. Nature Chemical Biology. 2018;14(11):1051-1058.

    • Koldewey P., Stull F., Horowitz S., Martin R., Bardwell J.C.A. Cell. 2016;166(2):369-379.

    • Stull F., Koldewey P., Humes J., Radford S., Bardwell J. Nature Structural and Molecular Biology. 2016;23(1):53-58.

    • Stull F.W., Bernard S.M., Sapra A., Smith J.L., Zuiderweg E.R.P., Palfey B.A. Biochemistry. 2016;55(23):3261-3269.

    • Teufel R., Stull F., Meehan M., Michaudel Q., Dorrestein P., Palfey B., Moore B. Journal of the American Chemical Society. 2015;137(25):8078-8085.

    • Nikolova E., Stull F., Al-Hashimi H.M. Biochemistry. 2014;53(46):7145-7147.

    • Teufel R., Miyanaga A., Michaudel Q., Stull F., Louie G., Noel J., Baran P., Palfey B., Moore B. Nature. 2013;503(7477):552-556.

    • Stull F.W., Martin D.F. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2009;44(14):1545-1550.

    • Martin D.F., Aguinaldo J.S., Kondis N.P., Stull F.W., O'Donnell L.F., Martin B.B., Alldredge R.L. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2008;43(11):1296-1302.